Transmembrane protein 220 (TMEM220)
Homo sapiens — UniProt Q6QAJ8
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 220 (TMEM220) is a protein from Homo sapiens identified by UniProt accession Q6QAJ8, 160 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q6QAJ8; gene symbol TMEM220.
- Organism: Homo sapiens.
- Length: 160 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hepatocellular carcinoma and intracerebral hemorrhage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 220 |
|---|---|
| UniProt accession | Q6QAJ8 |
| Gene | TMEM220 |
| Organism | Homo sapiens |
| Length | 160 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- hepatocellular carcinoma · score 0.10
- intracerebral hemorrhage · score 0.03
- neoplasm · score 0.03
- Acute hepatic failure · score 0.02
- Crohn's disease · score 0.02
- colorectal cancer · score 0.02
- breast carcinoma · score 0.01
- urothelial carcinoma · score 0.01
- gonorrhea · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6QAJ8-F1 | alphafold | PREDICTED | 91.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6QAJ8.
Amino-acid sequence (160 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM220?
The strongest Open Targets associations for TMEM220 are neurodegenerative disease, hepatocellular carcinoma, intracerebral hemorrhage, neoplasm and Acute hepatic failure.
How long is the TMEM220 protein?
The Homo sapiens TMEM220 protein (UniProt Q6QAJ8) is 160 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6QAJ8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6QAJ8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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