Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX)
Homo sapiens — UniProt Q6QHF9
Data last refreshed: (UniProt release unknown)
Key facts
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (PAOX) is a protein from Homo sapiens identified by UniProt accession Q6QHF9, 511 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q6QHF9; gene symbol PAOX.
- Organism: Homo sapiens.
- Length: 511 amino acids.
- Top disease associations (Open Targets): urinary metabolite measurement, serum metabolite measurement and blood metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase |
|---|---|
| UniProt accession | Q6QHF9 |
| Gene | PAOX |
| Organism | Homo sapiens |
| Length | 511 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.33
- serum metabolite measurement · score 0.30
- blood metabolite measurement · score 0.23
- glioblastoma multiforme · score 0.16
- urinary bladder cancer · score 0.11
- longevity · score 0.11
- Cerebral ischemia · score 0.04
- retinitis pigmentosa and erythrocytic microcytosis · score 0.04
- cancer · score 0.02
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6QHF9-F1 | alphafold | PREDICTED | 92.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6QHF9.
Amino-acid sequence (511 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAOX?
The strongest Open Targets associations for PAOX are urinary metabolite measurement, serum metabolite measurement, blood metabolite measurement, glioblastoma multiforme and urinary bladder cancer.
How long is the PAOX protein?
The Homo sapiens PAOX protein (UniProt Q6QHF9) is 511 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6QHF9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6QHF9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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