Factor in the germline alpha (FIGLA)
Homo sapiens — UniProt Q6QHK4
Data last refreshed: (UniProt release unknown)
Key facts
Factor in the germline alpha (FIGLA) is a protein from Homo sapiens identified by UniProt accession Q6QHK4, 219 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q6QHK4; gene symbol FIGLA.
- Organism: Homo sapiens.
- Length: 219 amino acids.
- Top disease associations (Open Targets): primary ovarian insufficiency, genetic non-acquired premature ovarian failure and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Factor in the germline alpha |
|---|---|
| UniProt accession | Q6QHK4 |
| Gene | FIGLA |
| Organism | Homo sapiens |
| Length | 219 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- primary ovarian insufficiency · score 0.60
- genetic non-acquired premature ovarian failure · score 0.35
- neurodegenerative disease · score 0.34
- premature menopause · score 0.24
- Premature ovarian insufficiency · score 0.23
- genetic disorder · score 0.18
- 46,XX gonadal dysgenesis · score 0.05
- Perrault syndrome · score 0.05
- 46,XY complete gonadal dysgenesis · score 0.05
- ring chromosome Y · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6QHK4-F1 | alphafold | PREDICTED | 71.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6QHK4.
Amino-acid sequence (219 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FIGLA?
The strongest Open Targets associations for FIGLA are primary ovarian insufficiency, genetic non-acquired premature ovarian failure, neurodegenerative disease, premature menopause and Premature ovarian insufficiency.
How long is the FIGLA protein?
The Homo sapiens FIGLA protein (UniProt Q6QHK4) is 219 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6QHK4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6QHK4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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