Ubiquitin carboxyl-terminal hydrolase 17 (USP17L2)
Homo sapiens — UniProt Q6R6M4
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 17 (USP17L2) is a protein from Homo sapiens identified by UniProt accession Q6R6M4, 530 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q6R6M4; gene symbol USP17L2.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Top disease associations (Open Targets): esophageal cancer, hepatocellular carcinoma and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 17 |
|---|---|
| UniProt accession | Q6R6M4 |
| Gene | USP17L2 |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- esophageal cancer · score 0.10
- hepatocellular carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.08
- neoplasm · score 0.08
- oral squamous cell carcinoma · score 0.08
- hypothyroidism · score 0.07
- cancer · score 0.05
- peak expiratory flow · score 0.04
- immunodeficiency 19 · score 0.04
- combined immunodeficiency with skin granulomas · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6R6M4-F1 | alphafold | PREDICTED | 67.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6R6M4.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP17L2?
The strongest Open Targets associations for USP17L2 are esophageal cancer, hepatocellular carcinoma, non-small cell lung carcinoma, neoplasm and oral squamous cell carcinoma.
How long is the USP17L2 protein?
The Homo sapiens USP17L2 protein (UniProt Q6R6M4) is 530 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6R6M4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6R6M4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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