von Hippel-Lindau-like protein (VHLL)
Homo sapiens — UniProt Q6RSH7
Data last refreshed: (UniProt release unknown)
Key facts
von Hippel-Lindau-like protein (VHLL) is a protein from Homo sapiens identified by UniProt accession Q6RSH7, 139 residues long. MolForge cross-references it against 0 known binders and 206 disease associations.
- UniProt accession: Q6RSH7; gene symbol VHLL.
- Organism: Homo sapiens.
- Length: 139 amino acids.
- Top disease associations (Open Targets): azoospermia, basophil count and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | von Hippel-Lindau-like protein |
|---|---|
| UniProt accession | Q6RSH7 |
| Gene | VHLL |
| Organism | Homo sapiens |
| Length | 139 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (206)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.07
- basophil count · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- Red cell distribution width · score 0.06
- mean corpuscular hemoglobin concentration · score 0.06
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 8 · score 0.06
- spermatogenic failure 51 · score 0.05
- non-alcoholic fatty liver disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6RSH7-F1 | alphafold | PREDICTED | 76.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6RSH7.
Amino-acid sequence (139 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VHLL?
The strongest Open Targets associations for VHLL are azoospermia, basophil count, male infertility with teratozoospermia due to single gene mutation, primary familial polycythemia due to EPO receptor mutation and Red cell distribution width.
How long is the VHLL protein?
The Homo sapiens VHLL protein (UniProt Q6RSH7) is 139 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6RSH7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6RSH7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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