SHC-transforming protein 4 (SHC4)
Homo sapiens — UniProt Q6S5L8
Data last refreshed: (UniProt release unknown)
Key facts
SHC-transforming protein 4 (SHC4) is a protein from Homo sapiens identified by UniProt accession Q6S5L8, 630 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q6S5L8; gene symbol SHC4.
- Organism: Homo sapiens.
- Length: 630 amino acids.
- Top disease associations (Open Targets): skin aging measurement, type 1 diabetes mellitus and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SHC-transforming protein 4 |
|---|---|
| UniProt accession | Q6S5L8 |
| Gene | SHC4 |
| Organism | Homo sapiens |
| Length | 630 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- skin aging measurement · score 0.40
- type 1 diabetes mellitus · score 0.33
- PHF-tau measurement · score 0.16
- diastolic blood pressure · score 0.09
- melanoma · score 0.09
- hepatocellular carcinoma · score 0.08
- mean platelet volume · score 0.07
- alcohol consumption measurement · score 0.06
- platelet count · score 0.06
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6S5L8-F1 | alphafold | PREDICTED | 58.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6S5L8.
Amino-acid sequence (630 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHC4?
The strongest Open Targets associations for SHC4 are skin aging measurement, type 1 diabetes mellitus, PHF-tau measurement, diastolic blood pressure and melanoma.
How long is the SHC4 protein?
The Homo sapiens SHC4 protein (UniProt Q6S5L8) is 630 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6S5L8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6S5L8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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