Zinc finger protein 474 (ZNF474)
Homo sapiens — UniProt Q6S9Z5
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 474 (ZNF474) is a protein from Homo sapiens identified by UniProt accession Q6S9Z5, 364 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q6S9Z5; gene symbol ZNF474.
- Organism: Homo sapiens.
- Length: 364 amino acids.
- Top disease associations (Open Targets): white matter hyperintensity measurement, hypertension and brain volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 474 |
|---|---|
| UniProt accession | Q6S9Z5 |
| Gene | ZNF474 |
| Organism | Homo sapiens |
| Length | 364 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- white matter hyperintensity measurement · score 0.47
- hypertension · score 0.38
- brain volume measurement · score 0.37
- Ischemic stroke · score 0.32
- stroke · score 0.32
- cortical surface area measurement · score 0.31
- cortical thickness · score 0.31
- neurodegenerative disease · score 0.26
- vital capacity · score 0.21
- Blackfan-Diamond anemia · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6S9Z5-F1 | alphafold | PREDICTED | 65.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6S9Z5.
Amino-acid sequence (364 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF474?
The strongest Open Targets associations for ZNF474 are white matter hyperintensity measurement, hypertension, brain volume measurement, Ischemic stroke and stroke.
How long is the ZNF474 protein?
The Homo sapiens ZNF474 protein (UniProt Q6S9Z5) is 364 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6S9Z5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6S9Z5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.