TATA box-binding protein-like 2 (TBPL2)
Homo sapiens — UniProt Q6SJ96
Data last refreshed: (UniProt release unknown)
Key facts
TATA box-binding protein-like 2 (TBPL2) is a protein from Homo sapiens identified by UniProt accession Q6SJ96, 343 residues long. MolForge cross-references it against 0 known binders and 141 disease associations.
- UniProt accession: Q6SJ96; gene symbol TBPL2.
- Organism: Homo sapiens.
- Length: 343 amino acids.
- Top disease associations (Open Targets): platelet count, femoral neck bone mineral density and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | TATA box-binding protein-like 2 |
|---|---|
| UniProt accession | Q6SJ96 |
| Gene | TBPL2 |
| Organism | Homo sapiens |
| Length | 343 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (141)
Diseases linked to this target (Open Targets).
- platelet count · score 0.31
- femoral neck bone mineral density · score 0.30
- glomerular filtration rate · score 0.27
- creatinine measurement · score 0.27
- neurofibrillary tangles measurement · score 0.21
- mean reticulocyte volume · score 0.10
- urate measurement · score 0.08
- bone density · score 0.07
- primary ovarian insufficiency · score 0.07
- Testicular Germ Cell Tumor · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6SJ96-F1 | alphafold | PREDICTED | 69.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6SJ96.
Amino-acid sequence (343 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TBPL2?
The strongest Open Targets associations for TBPL2 are platelet count, femoral neck bone mineral density, glomerular filtration rate, creatinine measurement and neurofibrillary tangles measurement.
How long is the TBPL2 protein?
The Homo sapiens TBPL2 protein (UniProt Q6SJ96) is 343 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6SJ96 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6SJ96 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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