Kelch-like protein 24 (KLHL24)
Homo sapiens — UniProt Q6TFL4
Data last refreshed: (UniProt release unknown)
Key facts
Kelch-like protein 24 (KLHL24) is a protein from Homo sapiens identified by UniProt accession Q6TFL4, 600 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: Q6TFL4; gene symbol KLHL24.
- Organism: Homo sapiens.
- Length: 600 amino acids.
- Top disease associations (Open Targets): epidermolysis bullosa simplex 6, generalized, with scarring and hair loss, cicatricial alopecia and cardiomyopathy, familial hypertrophic, 29, with polyglucosan bodies.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch-like protein 24 |
|---|---|
| UniProt accession | Q6TFL4 |
| Gene | KLHL24 |
| Organism | Homo sapiens |
| Length | 600 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- epidermolysis bullosa simplex 6, generalized, with scarring and hair loss · score 0.67
- cicatricial alopecia · score 0.51
- cardiomyopathy, familial hypertrophic, 29, with polyglucosan bodies · score 0.51
- Generalized epidermolysis bullosa simplex, non-Dowling-Meara type · score 0.48
- Basal epidermolysis bullosa simplex · score 0.37
- sex hormone-binding globulin measurement · score 0.36
- white matter hyperintensity measurement · score 0.33
- birth weight · score 0.33
- fat body mass · score 0.31
- cystatin C measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6TFL4-F1 | alphafold | PREDICTED | 87.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6TFL4.
Amino-acid sequence (600 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHL24?
The strongest Open Targets associations for KLHL24 are epidermolysis bullosa simplex 6, generalized, with scarring and hair loss, cicatricial alopecia, cardiomyopathy, familial hypertrophic, 29, with polyglucosan bodies, Generalized epidermolysis bullosa simplex, non-Dowling-Meara type and Basal epidermolysis bullosa simplex.
How long is the KLHL24 protein?
The Homo sapiens KLHL24 protein (UniProt Q6TFL4) is 600 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6TFL4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6TFL4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.