Kunitz-type protease inhibitor 4 (SPINT4)
Homo sapiens — UniProt Q6UDR6
Data last refreshed: (UniProt release unknown)
Key facts
Kunitz-type protease inhibitor 4 (SPINT4) is a protein from Homo sapiens identified by UniProt accession Q6UDR6, 99 residues long. MolForge cross-references it against 0 known binders and 3 disease associations.
- UniProt accession: Q6UDR6; gene symbol SPINT4.
- Organism: Homo sapiens.
- Length: 99 amino acids.
- Top disease associations (Open Targets): actinic keratosis, sebaceous of Jadassohn nevus and squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kunitz-type protease inhibitor 4 |
|---|---|
| UniProt accession | Q6UDR6 |
| Gene | SPINT4 |
| Organism | Homo sapiens |
| Length | 99 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (3)
Diseases linked to this target (Open Targets).
- actinic keratosis · score 0.05
- sebaceous of Jadassohn nevus · score 0.05
- squamous cell carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UDR6-F1 | alphafold | PREDICTED | 91.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UDR6.
Amino-acid sequence (99 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPINT4?
The strongest Open Targets associations for SPINT4 are actinic keratosis, sebaceous of Jadassohn nevus and squamous cell carcinoma.
How long is the SPINT4 protein?
The Homo sapiens SPINT4 protein (UniProt Q6UDR6) is 99 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UDR6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UDR6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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