Placenta-expressed transcript 1 protein (PLET1)
Homo sapiens — UniProt Q6UQ28
Data last refreshed: (UniProt release unknown)
Key facts
Placenta-expressed transcript 1 protein (PLET1) is a protein from Homo sapiens identified by UniProt accession Q6UQ28, 207 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q6UQ28; gene symbol PLET1.
- Organism: Homo sapiens.
- Length: 207 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, bone quantitative ultrasound measurement and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Placenta-expressed transcript 1 protein |
|---|---|
| UniProt accession | Q6UQ28 |
| Gene | PLET1 |
| Organism | Homo sapiens |
| Length | 207 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.21
- bone quantitative ultrasound measurement · score 0.20
- blood protein measurement · score 0.19
- bone density · score 0.17
- hyperinsulinism due to INSR deficiency · score 0.06
- hyperinsulinism due to glucokinase deficiency · score 0.05
- hypoparathyroidism, familial isolated, 2 · score 0.05
- exercise-induced hyperinsulinism · score 0.05
- hyperinsulinism-hyperammonemia syndrome · score 0.05
- hyperproinsulinemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UQ28-F1 | alphafold | PREDICTED | 76.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UQ28.
Amino-acid sequence (207 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLET1?
The strongest Open Targets associations for PLET1 are heel bone mineral density, bone quantitative ultrasound measurement, blood protein measurement, bone density and hyperinsulinism due to INSR deficiency.
How long is the PLET1 protein?
The Homo sapiens PLET1 protein (UniProt Q6UQ28) is 207 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UQ28 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UQ28 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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