CREB-regulated transcription coactivator 3 (CRTC3)
Homo sapiens — UniProt Q6UUV7
Data last refreshed: (UniProt release unknown)
Key facts
CREB-regulated transcription coactivator 3 (CRTC3) is a protein from Homo sapiens identified by UniProt accession Q6UUV7, 619 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.
- UniProt accession: Q6UUV7; gene symbol CRTC3.
- Organism: Homo sapiens.
- Length: 619 amino acids.
- Top disease associations (Open Targets): oral squamous cell carcinoma, Salivary Gland Pleomorphic Adenoma and salivary gland mucoepidermoid carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CREB-regulated transcription coactivator 3 |
|---|---|
| UniProt accession | Q6UUV7 |
| Gene | CRTC3 |
| Organism | Homo sapiens |
| Length | 619 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (174)
Diseases linked to this target (Open Targets).
- oral squamous cell carcinoma · score 0.37
- Salivary Gland Pleomorphic Adenoma · score 0.37
- salivary gland mucoepidermoid carcinoma · score 0.37
- mucoepidermoid carcinoma of parotid gland · score 0.37
- heel bone mineral density · score 0.35
- eosinophil count · score 0.32
- salivary gland adenoid cystic carcinoma · score 0.28
- eosinophil percentage of leukocytes · score 0.24
- skin pigmentation · score 0.24
- total blood protein measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UUV7-F1 | alphafold | PREDICTED | 49.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UUV7.
Amino-acid sequence (619 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CRTC3?
The strongest Open Targets associations for CRTC3 are oral squamous cell carcinoma, Salivary Gland Pleomorphic Adenoma, salivary gland mucoepidermoid carcinoma, mucoepidermoid carcinoma of parotid gland and heel bone mineral density.
How long is the CRTC3 protein?
The Homo sapiens CRTC3 protein (UniProt Q6UUV7) is 619 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UUV7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UUV7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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