CREB-regulated transcription coactivator 1 (CRTC1)
Homo sapiens — UniProt Q6UUV9
Data last refreshed: (UniProt release unknown)
Key facts
CREB-regulated transcription coactivator 1 (CRTC1) is a protein from Homo sapiens identified by UniProt accession Q6UUV9, 634 residues long. MolForge cross-references it against 0 known binders and 382 disease associations.
- UniProt accession: Q6UUV9; gene symbol CRTC1.
- Organism: Homo sapiens.
- Length: 634 amino acids.
- Top disease associations (Open Targets): esophageal adenocarcinoma, body mass index and kidney neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CREB-regulated transcription coactivator 1 |
|---|---|
| UniProt accession | Q6UUV9 |
| Gene | CRTC1 |
| Organism | Homo sapiens |
| Length | 634 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (382)
Diseases linked to this target (Open Targets).
- esophageal adenocarcinoma · score 0.45
- body mass index · score 0.40
- kidney neoplasm · score 0.38
- salivary gland mucoepidermoid carcinoma · score 0.37
- pulmonary mucoepidermoid carcinoma · score 0.37
- Cervical Adenosquamous Carcinoma · score 0.37
- lymphoid neoplasm · score 0.37
- adenosquamous lung carcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
- gastric carcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UUV9-F1 | alphafold | PREDICTED | 51.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UUV9.
Amino-acid sequence (634 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CRTC1?
The strongest Open Targets associations for CRTC1 are esophageal adenocarcinoma, body mass index, kidney neoplasm, salivary gland mucoepidermoid carcinoma and pulmonary mucoepidermoid carcinoma.
How long is the CRTC1 protein?
The Homo sapiens CRTC1 protein (UniProt Q6UUV9) is 634 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UUV9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UUV9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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