Spindle assembly abnormal protein 6 homolog (SASS6)
Homo sapiens — UniProt Q6UVJ0
Data last refreshed: (UniProt release unknown)
Key facts
Spindle assembly abnormal protein 6 homolog (SASS6) is a protein from Homo sapiens identified by UniProt accession Q6UVJ0, 657 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q6UVJ0; gene symbol SASS6.
- Organism: Homo sapiens.
- Length: 657 amino acids.
- Top disease associations (Open Targets): autosomal recessive primary microcephaly, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Spindle assembly abnormal protein 6 homolog |
|---|---|
| UniProt accession | Q6UVJ0 |
| Gene | SASS6 |
| Organism | Homo sapiens |
| Length | 657 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- autosomal recessive primary microcephaly · score 0.58
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.22
- Visual loss · score 0.08
- open-angle glaucoma · score 0.03
- body height · score 0.03
- leukocyte count · score 0.02
- esophageal squamous cell carcinoma · score 0.02
- Microcephaly · score 0.02
- triple-negative breast cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UVJ0-F1 | alphafold | PREDICTED | 73.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UVJ0.
Amino-acid sequence (657 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SASS6?
The strongest Open Targets associations for SASS6 are autosomal recessive primary microcephaly, genetic disorder, neurodegenerative disease, Visual loss and open-angle glaucoma.
How long is the SASS6 protein?
The Homo sapiens SASS6 protein (UniProt Q6UVJ0) is 657 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UVJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UVJ0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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