Sperm equatorial segment protein 1 (SPESP1)
Homo sapiens — UniProt Q6UW49
Data last refreshed: (UniProt release unknown)
Key facts
Sperm equatorial segment protein 1 (SPESP1) is a protein from Homo sapiens identified by UniProt accession Q6UW49, 350 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.
- UniProt accession: Q6UW49; gene symbol SPESP1.
- Organism: Homo sapiens.
- Length: 350 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, esophageal carcinoma and Agents acting on the renin-angiotensin system use measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm equatorial segment protein 1 |
|---|---|
| UniProt accession | Q6UW49 |
| Gene | SPESP1 |
| Organism | Homo sapiens |
| Length | 350 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- esophageal carcinoma · score 0.14
- Agents acting on the renin-angiotensin system use measurement · score 0.12
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- neoplasm · score 0.08
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 49 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UW49-F1 | alphafold | PREDICTED | 57.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UW49.
Amino-acid sequence (350 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPESP1?
The strongest Open Targets associations for SPESP1 are neurodegenerative disease, esophageal carcinoma, Agents acting on the renin-angiotensin system use measurement, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the SPESP1 protein?
The Homo sapiens SPESP1 protein (UniProt Q6UW49) is 350 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UW49 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UW49 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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