Proprotein convertase subtilisin/kexin type 4 (PCSK4)
Homo sapiens — UniProt Q6UW60
Data last refreshed: (UniProt release unknown)
Key facts
Proprotein convertase subtilisin/kexin type 4 (PCSK4) is a protein from Homo sapiens identified by UniProt accession Q6UW60, 755 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q6UW60; gene symbol PCSK4.
- Organism: Homo sapiens.
- Length: 755 amino acids.
- Top disease associations (Open Targets): breast ductal adenocarcinoma, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proprotein convertase subtilisin/kexin type 4 |
|---|---|
| UniProt accession | Q6UW60 |
| Gene | PCSK4 |
| Organism | Homo sapiens |
| Length | 755 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- breast ductal adenocarcinoma · score 0.11
- azoospermia · score 0.10
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 72 · score 0.07
- spermatogenic failure 27 · score 0.07
- spermatogenic failure 18 · score 0.07
- spermatogenic failure 46 · score 0.07
- spermatogenic failure 65 · score 0.07
- spermatogenic failure 49 · score 0.07
- spermatogenic failure 43 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UW60-F1 | alphafold | PREDICTED | 84.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UW60.
Amino-acid sequence (755 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCSK4?
The strongest Open Targets associations for PCSK4 are breast ductal adenocarcinoma, azoospermia, male infertility with teratozoospermia due to single gene mutation, spermatogenic failure 72 and spermatogenic failure 27.
How long is the PCSK4 protein?
The Homo sapiens PCSK4 protein (UniProt Q6UW60) is 755 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UW60 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UW60 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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