Transmembrane protein 205 (TMEM205)
Homo sapiens — UniProt Q6UW68
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 205 (TMEM205) is a protein from Homo sapiens identified by UniProt accession Q6UW68, 189 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q6UW68; gene symbol TMEM205.
- Organism: Homo sapiens.
- Length: 189 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, hepatocellular carcinoma and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 205 |
|---|---|
| UniProt accession | Q6UW68 |
| Gene | TMEM205 |
| Organism | Homo sapiens |
| Length | 189 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- hepatocellular carcinoma · score 0.04
- neoplasm · score 0.04
- low density lipoprotein cholesterol measurement · score 0.02
- pancreatic adenocarcinoma · score 0.02
- ovarian clear cell cancer · score 0.01
- Alzheimer disease · score 0.01
- gonorrhea · score 0.01
- cancer · score 0.01
- squamous cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UW68-F1 | alphafold | PREDICTED | 93.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UW68.
Amino-acid sequence (189 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM205?
The strongest Open Targets associations for TMEM205 are neurodegenerative disease, hepatocellular carcinoma, neoplasm, low density lipoprotein cholesterol measurement and pancreatic adenocarcinoma.
How long is the TMEM205 protein?
The Homo sapiens TMEM205 protein (UniProt Q6UW68) is 189 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UW68 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UW68 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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