Interleukin-27 receptor subunit alpha (IL27RA)
Homo sapiens — UniProt Q6UWB1
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-27 receptor subunit alpha (IL27RA) is a protein from Homo sapiens identified by UniProt accession Q6UWB1, 636 residues long. MolForge cross-references it against 0 known binders and 230 disease associations.
- UniProt accession: Q6UWB1; gene symbol IL27RA.
- Organism: Homo sapiens.
- Length: 636 amino acids.
- Top disease associations (Open Targets): lymphocyte count, platelet count and lymphocyte percentage of leukocytes.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-27 receptor subunit alpha |
|---|---|
| UniProt accession | Q6UWB1 |
| Gene | IL27RA |
| Organism | Homo sapiens |
| Length | 636 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (230)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.38
- platelet count · score 0.36
- lymphocyte percentage of leukocytes · score 0.35
- neutrophil percentage of leukocytes · score 0.35
- leukocyte count · score 0.32
- cerebrospinal fluid biomarker measurement · score 0.27
- interleukin 27 receptor subunit alpha measurement · score 0.27
- HbA1c measurement · score 0.27
- platelet crit · score 0.25
- lung adenocarcinoma · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWB1-F1 | alphafold | PREDICTED | 78.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWB1.
Amino-acid sequence (636 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL27RA?
The strongest Open Targets associations for IL27RA are lymphocyte count, platelet count, lymphocyte percentage of leukocytes, neutrophil percentage of leukocytes and leukocyte count.
How long is the IL27RA protein?
The Homo sapiens IL27RA protein (UniProt Q6UWB1) is 636 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWB1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWB1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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