E3 ubiquitin-protein ligase LRSAM1 (LRSAM1)
Homo sapiens — UniProt Q6UWE0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase LRSAM1 (LRSAM1) is a protein from Homo sapiens identified by UniProt accession Q6UWE0, 723 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q6UWE0; gene symbol LRSAM1.
- Organism: Homo sapiens.
- Length: 723 amino acids.
- Top disease associations (Open Targets): Charcot-Marie-Tooth disease axonal type 2P, Charcot-Marie-Tooth disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase LRSAM1 |
|---|---|
| UniProt accession | Q6UWE0 |
| Gene | LRSAM1 |
| Organism | Homo sapiens |
| Length | 723 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease axonal type 2P · score 0.79
- Charcot-Marie-Tooth disease · score 0.57
- genetic disorder · score 0.52
- Charcot-Marie-Tooth disease type 2 · score 0.17
- platelet count · score 0.11
- Charcot-Marie-Tooth disease type 4 · score 0.11
- Charcot-Marie-Tooth disease type 1 · score 0.11
- mean corpuscular hemoglobin · score 0.10
- mean corpuscular volume · score 0.10
- mean corpuscular hemoglobin concentration · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWE0-F1 | alphafold | PREDICTED | 78.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWE0.
Amino-acid sequence (723 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRSAM1?
The strongest Open Targets associations for LRSAM1 are Charcot-Marie-Tooth disease axonal type 2P, Charcot-Marie-Tooth disease, genetic disorder, Charcot-Marie-Tooth disease type 2 and platelet count.
How long is the LRSAM1 protein?
The Homo sapiens LRSAM1 protein (UniProt Q6UWE0) is 723 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWE0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWE0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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