Colipase-like protein 2 (CLPSL2)
Homo sapiens — UniProt Q6UWE3
Data last refreshed: (UniProt release unknown)
Key facts
Colipase-like protein 2 (CLPSL2) is a protein from Homo sapiens identified by UniProt accession Q6UWE3, 100 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q6UWE3; gene symbol CLPSL2.
- Organism: Homo sapiens.
- Length: 100 amino acids.
- Top disease associations (Open Targets): age-related macular degeneration, X-linked retinal dysplasia and retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Colipase-like protein 2 |
|---|---|
| UniProt accession | Q6UWE3 |
| Gene | CLPSL2 |
| Organism | Homo sapiens |
| Length | 100 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.08
- retinitis pigmentosa · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 11 · score 0.06
- age related macular degeneration 4 · score 0.06
- age related macular degeneration 7 · score 0.06
- Leber congenital amaurosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWE3-F1 | alphafold | PREDICTED | 82.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWE3.
Amino-acid sequence (100 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLPSL2?
The strongest Open Targets associations for CLPSL2 are age-related macular degeneration, X-linked retinal dysplasia, retinitis pigmentosa, choroidal dystrophy, central areolar, 1 and Familial exudative vitreoretinopathy.
How long is the CLPSL2 protein?
The Homo sapiens CLPSL2 protein (UniProt Q6UWE3) is 100 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWE3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWE3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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