SLP adapter and CSK-interacting membrane protein…

About SLP adapter and CSK-interacting membrane protein

SLP adapter and CSK-interacting membrane protein (SCIMP) is a protein from Homo sapiens identified by UniProt accession Q6UWF3, 145 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	SLP adapter and CSK-interacting membrane protein
UniProt accession	Q6UWF3
Gene	SCIMP
Organism	Homo sapiens
Length	145 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

family history of Alzheimer’s disease · score 0.18
Alzheimer disease · score 0.16
platelet component distribution width · score 0.13
head and neck malignant neoplasia · score 0.11
Blackfan-Diamond anemia · score 0.07
Adult-onset autosomal recessive sideroblastic anemia · score 0.05
hemoglobin E-beta-thalassemia syndrome · score 0.05
Rh deficiency syndrome · score 0.04
X-linked sideroblastic anemia 1 · score 0.04
cholesterol-ester transfer protein deficiency · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UWF3-F1	alphafold	PREDICTED	66.62	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWF3.

Amino-acid sequence (145 residues)

MDTFTVQDST AMSWWRNNFW IILAVAIIVV SVGLGLILYC VCKWQLRRGK KWEIAKPLKH KQVDEEKMYE NVLNESPVQL PPLPPRNWPS LEDSSPQEAP SQPPATYSLV NKVKNKKTVS IPSYIEPEDD YDDVEIPANT EKASF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

SLP adapter and CSK-interacting membrane protein (SCIMP)