NXPE family member 4 (NXPE4)
Homo sapiens — UniProt Q6UWF7
Data last refreshed: (UniProt release unknown)
Key facts
NXPE family member 4 (NXPE4) is a protein from Homo sapiens identified by UniProt accession Q6UWF7, 544 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q6UWF7; gene symbol NXPE4.
- Organism: Homo sapiens.
- Length: 544 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and inflammatory bowel disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NXPE family member 4 |
|---|---|
| UniProt accession | Q6UWF7 |
| Gene | NXPE4 |
| Organism | Homo sapiens |
| Length | 544 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- ulcerative colitis · score 0.23
- inflammatory bowel disease · score 0.17
- Crohn's disease · score 0.11
- ankylosing spondylitis · score 0.10
- psoriasis · score 0.10
- sclerosing cholangitis · score 0.10
- gut microbiome measurement · score 0.05
- PHF-tau measurement · score 0.05
- blood protein measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWF7-F1 | alphafold | PREDICTED | 90.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWF7.
Amino-acid sequence (544 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NXPE4?
The strongest Open Targets associations for NXPE4 are neurodegenerative disease, ulcerative colitis, inflammatory bowel disease, Crohn's disease and ankylosing spondylitis.
How long is the NXPE4 protein?
The Homo sapiens NXPE4 protein (UniProt Q6UWF7) is 544 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWF7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWF7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.