Protein shisa-2 homolog (SHISA2)
Homo sapiens — UniProt Q6UWI4
Data last refreshed: (UniProt release unknown)
Key facts
Protein shisa-2 homolog (SHISA2) is a protein from Homo sapiens identified by UniProt accession Q6UWI4, 295 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q6UWI4; gene symbol SHISA2.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, adolescent idiopathic scoliosis and cortical surface area measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein shisa-2 homolog |
|---|---|
| UniProt accession | Q6UWI4 |
| Gene | SHISA2 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.32
- adolescent idiopathic scoliosis · score 0.21
- cortical surface area measurement · score 0.08
- pachyonychia congenita · score 0.06
- brain measurement · score 0.06
- Mobius syndrome · score 0.04
- pancreatic adenocarcinoma · score 0.04
- short stature due to GHSR deficiency · score 0.04
- clear cell renal carcinoma · score 0.03
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWI4-F1 | alphafold | PREDICTED | 63.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWI4.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHISA2?
The strongest Open Targets associations for SHISA2 are PHF-tau measurement, adolescent idiopathic scoliosis, cortical surface area measurement, pachyonychia congenita and brain measurement.
How long is the SHISA2 protein?
The Homo sapiens SHISA2 protein (UniProt Q6UWI4) is 295 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWI4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWI4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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