Kin of IRRE-like protein 2 (KIRREL2)
Homo sapiens — UniProt Q6UWL6
Data last refreshed: (UniProt release unknown)
Key facts
Kin of IRRE-like protein 2 (KIRREL2) is a protein from Homo sapiens identified by UniProt accession Q6UWL6, 708 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q6UWL6; gene symbol KIRREL2.
- Organism: Homo sapiens.
- Length: 708 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, glioblastoma multiforme and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kin of IRRE-like protein 2 |
|---|---|
| UniProt accession | Q6UWL6 |
| Gene | KIRREL2 |
| Organism | Homo sapiens |
| Length | 708 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.23
- glioblastoma multiforme · score 0.23
- head and neck squamous cell carcinoma · score 0.18
- endometrial cancer · score 0.18
- urinary metabolite measurement · score 0.13
- Neurodevelopmental delay · score 0.12
- epilepsy · score 0.12
- vitamin D measurement · score 0.10
- Mobius syndrome · score 0.07
- creatinine measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWL6-F1 | alphafold | PREDICTED | 75.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWL6.
Amino-acid sequence (708 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KIRREL2?
The strongest Open Targets associations for KIRREL2 are breast adenocarcinoma, glioblastoma multiforme, head and neck squamous cell carcinoma, endometrial cancer and urinary metabolite measurement.
How long is the KIRREL2 protein?
The Homo sapiens KIRREL2 protein (UniProt Q6UWL6) is 708 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWL6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWL6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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