Myelin protein zero-like protein 3 (MPZL3)
Homo sapiens — UniProt Q6UWV2
Data last refreshed: (UniProt release unknown)
Key facts
Myelin protein zero-like protein 3 (MPZL3) is a protein from Homo sapiens identified by UniProt accession Q6UWV2, 235 residues long. MolForge cross-references it against 0 known binders and 225 disease associations.
- UniProt accession: Q6UWV2; gene symbol MPZL3.
- Organism: Homo sapiens.
- Length: 235 amino acids.
- Top disease associations (Open Targets): non-small cell lung carcinoma, neurodegenerative disease and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Myelin protein zero-like protein 3 |
|---|---|
| UniProt accession | Q6UWV2 |
| Gene | MPZL3 |
| Organism | Homo sapiens |
| Length | 235 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (225)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.31
- neurodegenerative disease · score 0.31
- lung adenocarcinoma · score 0.31
- neutrophil count · score 0.25
- monocyte percentage of leukocytes · score 0.22
- sum of basophil and neutrophil counts · score 0.20
- lung carcinoma · score 0.17
- cancer · score 0.09
- hypotrichosis simplex · score 0.08
- Alopecia-intellectual disability syndrome · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWV2-F1 | alphafold | PREDICTED | 80.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWV2.
Amino-acid sequence (235 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MPZL3?
The strongest Open Targets associations for MPZL3 are non-small cell lung carcinoma, neurodegenerative disease, lung adenocarcinoma, neutrophil count and monocyte percentage of leukocytes.
How long is the MPZL3 protein?
The Homo sapiens MPZL3 protein (UniProt Q6UWV2) is 235 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWV2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWV2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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