Arylsulfatase K (ARSK)
Homo sapiens — UniProt Q6UWY0
Data last refreshed: (UniProt release unknown)
Key facts
Arylsulfatase K (ARSK) is a protein from Homo sapiens identified by UniProt accession Q6UWY0, 536 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q6UWY0; gene symbol ARSK.
- Organism: Homo sapiens.
- Length: 536 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, pancreatic adenocarcinoma and retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Arylsulfatase K |
|---|---|
| UniProt accession | Q6UWY0 |
| Gene | ARSK |
| Organism | Homo sapiens |
| Length | 536 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- pancreatic adenocarcinoma · score 0.21
- retinitis pigmentosa · score 0.11
- X-linked retinal dysplasia · score 0.10
- age-related macular degeneration · score 0.09
- Progressive cone dystrophy · score 0.09
- severe early-childhood-onset retinal dystrophy · score 0.08
- choroidal dystrophy, central areolar, 1 · score 0.08
- Familial exudative vitreoretinopathy · score 0.08
- age related macular degeneration 4 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWY0-F1 | alphafold | PREDICTED | 91.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWY0.
Amino-acid sequence (536 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARSK?
The strongest Open Targets associations for ARSK are neurodegenerative disease, pancreatic adenocarcinoma, retinitis pigmentosa, X-linked retinal dysplasia and age-related macular degeneration.
How long is the ARSK protein?
The Homo sapiens ARSK protein (UniProt Q6UWY0) is 536 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWY0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWY0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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