Serine protease 57 (PRSS57)
Homo sapiens — UniProt Q6UWY2
Data last refreshed: (UniProt release unknown)
Key facts
Serine protease 57 (PRSS57) is a protein from Homo sapiens identified by UniProt accession Q6UWY2, 283 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q6UWY2; gene symbol PRSS57.
- Organism: Homo sapiens.
- Length: 283 amino acids.
- Top disease associations (Open Targets): blood protein measurement, neutrophil immunodeficiency syndrome and Recurrent infection due to specific granule deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine protease 57 |
|---|---|
| UniProt accession | Q6UWY2 |
| Gene | PRSS57 |
| Organism | Homo sapiens |
| Length | 283 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.33
- neutrophil immunodeficiency syndrome · score 0.07
- Recurrent infection due to specific granule deficiency · score 0.05
- neutropenia-monocytopenia-deafness syndrome · score 0.04
- Testicular regression syndrome · score 0.03
- 46,XX ovotesticular disorder of sex development · score 0.03
- Barth syndrome · score 0.03
- testicular agenesis · score 0.03
- chronic myelogenous leukemia · score 0.03
- 46,XY sex reversal 3 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWY2-F1 | alphafold | PREDICTED | 89.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWY2.
Amino-acid sequence (283 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRSS57?
The strongest Open Targets associations for PRSS57 are blood protein measurement, neutrophil immunodeficiency syndrome, Recurrent infection due to specific granule deficiency, neutropenia-monocytopenia-deafness syndrome and Testicular regression syndrome.
How long is the PRSS57 protein?
The Homo sapiens PRSS57 protein (UniProt Q6UWY2) is 283 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWY2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWY2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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