BRCA1-A complex subunit Abraxas 1 (ABRAXAS1)
Homo sapiens — UniProt Q6UWZ7
Data last refreshed: (UniProt release unknown)
Key facts
BRCA1-A complex subunit Abraxas 1 (ABRAXAS1) is a protein from Homo sapiens identified by UniProt accession Q6UWZ7, 409 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q6UWZ7; gene symbol ABRAXAS1.
- Organism: Homo sapiens.
- Length: 409 amino acids.
- Top disease associations (Open Targets): breast carcinoma, hereditary breast carcinoma and Hereditary breast cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BRCA1-A complex subunit Abraxas 1 |
|---|---|
| UniProt accession | Q6UWZ7 |
| Gene | ABRAXAS1 |
| Organism | Homo sapiens |
| Length | 409 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- breast carcinoma · score 0.54
- hereditary breast carcinoma · score 0.50
- Hereditary breast cancer · score 0.50
- breast neoplasm · score 0.50
- hereditary neoplastic syndrome · score 0.40
- Inherited cancer-predisposing syndrome · score 0.40
- Hereditary breast and ovarian cancer syndrome · score 0.33
- hereditary breast ovarian cancer syndrome · score 0.33
- age at menopause · score 0.24
- menopause · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UWZ7-F1 | alphafold | PREDICTED | 77.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UWZ7.
Amino-acid sequence (409 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABRAXAS1?
The strongest Open Targets associations for ABRAXAS1 are breast carcinoma, hereditary breast carcinoma, Hereditary breast cancer, breast neoplasm and hereditary neoplastic syndrome.
How long is the ABRAXAS1 protein?
The Homo sapiens ABRAXAS1 protein (UniProt Q6UWZ7) is 409 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UWZ7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UWZ7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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