Peptidase inhibitor 16 (PI16)

About Peptidase inhibitor 16

Peptidase inhibitor 16 (PI16) is a protein from Homo sapiens identified by UniProt accession Q6UXB8, 463 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Peptidase inhibitor 16
UniProt accession	Q6UXB8
Gene	PI16
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
type 2 diabetes mellitus · score 0.24
hepatocellular carcinoma · score 0.08
myocardial infarction · score 0.07
esophageal squamous cell carcinoma · score 0.07
bladder transitional cell carcinoma · score 0.06
breast carcinoma · score 0.06
hemoglobin measurement · score 0.05
erythrocyte count · score 0.05
low density lipoprotein cholesterol measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6UXB8-F1	alphafold	PREDICTED	62.33	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UXB8.

Amino-acid sequence (463 residues)

MHGSCSFLML LLPLLLLLVA TTGPVGALTD EEKRLMVELH NLYRAQVSPT ASDMLHMRWD EELAAFAKAY ARQCVWGHNK ERGRRGENLF AITDEGMDVP LAMEEWHHER EHYNLSAATC SPGQMCGHYT QVVWAKTERI GCGSHFCEKL QGVEETNIEL LVCNYEPPGN VKGKRPYQEG TPCSQCPSGY HCKNSLCEPI GSPEDAQDLP YLVTEAPSFR ATEASDSRKM GTPSSLATGI PAFLVTEVSG SLATKALPAV ETQAPTSLAT KDPPSMATEA PPCVTTEVPS ILAAHSLPSL DEEPVTFPKS THVPIPKSAD KVTDKTKVPS RSPENSLDPK MSLTGARELL PHAQEEAEAE AELPPSSEVL ASVFPAQDKP GELQATLDHT GHTSSKSLPN FPNTSATANA TGGRALALQS SLPGAEGPDK PSVVSGLNSG PGHVWGPLLG LLLLPPLVLA GIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards