Angiopoietin-like protein 8 (ANGPTL8)
Homo sapiens — UniProt Q6UXH0
Data last refreshed: (UniProt release unknown)
Key facts
Angiopoietin-like protein 8 (ANGPTL8) is a protein from Homo sapiens identified by UniProt accession Q6UXH0, 198 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.
- UniProt accession: Q6UXH0; gene symbol ANGPTL8.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, triglyceride measurement and triglyceride:HDL cholesterol ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Angiopoietin-like protein 8 |
|---|---|
| UniProt accession | Q6UXH0 |
| Gene | ANGPTL8 |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (183)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.64
- triglyceride measurement · score 0.62
- triglyceride:HDL cholesterol ratio · score 0.42
- lipoprotein measurement · score 0.38
- triglycerides:total lipids ratio · score 0.37
- apolipoprotein A 1 measurement · score 0.34
- total cholesterol measurement · score 0.29
- serum metabolite measurement · score 0.28
- Red cell distribution width · score 0.28
- Adams-Oliver syndrome · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UXH0-F1 | alphafold | PREDICTED | 84.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UXH0.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANGPTL8?
The strongest Open Targets associations for ANGPTL8 are high density lipoprotein cholesterol measurement, triglyceride measurement, triglyceride:HDL cholesterol ratio, lipoprotein measurement and triglycerides:total lipids ratio.
How long is the ANGPTL8 protein?
The Homo sapiens ANGPTL8 protein (UniProt Q6UXH0) is 198 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UXH0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UXH0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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