Inter-alpha-trypsin inhibitor heavy chain H6 (ITIH6)
Homo sapiens — UniProt Q6UXX5
Data last refreshed: (UniProt release unknown)
Key facts
Inter-alpha-trypsin inhibitor heavy chain H6 (ITIH6) is a protein from Homo sapiens identified by UniProt accession Q6UXX5, 1313 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q6UXX5; gene symbol ITIH6.
- Organism: Homo sapiens.
- Length: 1313 amino acids.
- Top disease associations (Open Targets): Short stature, Abnormality of the digestive system and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inter-alpha-trypsin inhibitor heavy chain H6 |
|---|---|
| UniProt accession | Q6UXX5 |
| Gene | ITIH6 |
| Organism | Homo sapiens |
| Length | 1313 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- Short stature · score 0.36
- Abnormality of the digestive system · score 0.33
- Intellectual disability · score 0.12
- non-small cell lung carcinoma · score 0.03
- Neurodevelopmental disorder · score 0.01
- neoplasm · score 0.00
- melanoma · score 0.00
- Pituitary prolactin cell adenoma · score 0.00
- cancer · score 0.00
- pachyonychia congenita · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UXX5-F1 | alphafold | PREDICTED | 64.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UXX5.
Amino-acid sequence (1313 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ITIH6?
The strongest Open Targets associations for ITIH6 are Short stature, Abnormality of the digestive system, Intellectual disability, non-small cell lung carcinoma and Neurodevelopmental disorder.
How long is the ITIH6 protein?
The Homo sapiens ITIH6 protein (UniProt Q6UXX5) is 1313 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UXX5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UXX5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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