R-spondin-2 (RSPO2)
Homo sapiens — UniProt Q6UXX9
Data last refreshed: (UniProt release unknown)
Key facts
R-spondin-2 (RSPO2) is a protein from Homo sapiens identified by UniProt accession Q6UXX9, 243 residues long. MolForge cross-references it against 0 known binders and 845 disease associations.
- UniProt accession: Q6UXX9; gene symbol RSPO2.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): humerofemoral hypoplasia with radiotibial ray deficiency, Tetraamelia - multiple malformations and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | R-spondin-2 |
|---|---|
| UniProt accession | Q6UXX9 |
| Gene | RSPO2 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (845)
Diseases linked to this target (Open Targets).
- humerofemoral hypoplasia with radiotibial ray deficiency · score 0.55
- Tetraamelia - multiple malformations · score 0.50
- heel bone mineral density · score 0.44
- hair shape measurement · score 0.42
- body height · score 0.38
- hair colour measurement · score 0.38
- esophageal adenocarcinoma · score 0.37
- gastric carcinoma · score 0.37
- prostate carcinoma · score 0.37
- breast ductal adenocarcinoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UXX9-F1 | alphafold | PREDICTED | 81.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UXX9.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RSPO2?
The strongest Open Targets associations for RSPO2 are humerofemoral hypoplasia with radiotibial ray deficiency, Tetraamelia - multiple malformations, heel bone mineral density, hair shape measurement and body height.
How long is the RSPO2 protein?
The Homo sapiens RSPO2 protein (UniProt Q6UXX9) is 243 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UXX9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UXX9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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