ADAMTS-like protein 4 (ADAMTSL4)
Homo sapiens — UniProt Q6UY14
Data last refreshed: (UniProt release unknown)
Key facts
ADAMTS-like protein 4 (ADAMTSL4) is a protein from Homo sapiens identified by UniProt accession Q6UY14, 1074 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q6UY14; gene symbol ADAMTSL4.
- Organism: Homo sapiens.
- Length: 1074 amino acids.
- Top disease associations (Open Targets): isolated ectopia lentis, body height and craniosynostosis with ectopia lentis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADAMTS-like protein 4 |
|---|---|
| UniProt accession | Q6UY14 |
| Gene | ADAMTSL4 |
| Organism | Homo sapiens |
| Length | 1074 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- isolated ectopia lentis · score 0.73
- body height · score 0.52
- craniosynostosis with ectopia lentis · score 0.51
- forced expiratory volume · score 0.35
- monocyte count · score 0.28
- monocyte percentage of leukocytes · score 0.27
- appendicular lean mass · score 0.26
- FEV change measurement · score 0.25
- mean corpuscular volume · score 0.23
- head and neck squamous cell carcinoma · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UY14-F1 | alphafold | PREDICTED | 64.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UY14.
Amino-acid sequence (1074 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTSL4?
The strongest Open Targets associations for ADAMTSL4 are isolated ectopia lentis, body height, craniosynostosis with ectopia lentis, forced expiratory volume and monocyte count.
How long is the ADAMTSL4 protein?
The Homo sapiens ADAMTSL4 protein (UniProt Q6UY14) is 1074 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UY14 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UY14 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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