Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (LINGO4)
Homo sapiens — UniProt Q6UY18
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (LINGO4) is a protein from Homo sapiens identified by UniProt accession Q6UY18, 593 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q6UY18; gene symbol LINGO4.
- Organism: Homo sapiens.
- Length: 593 amino acids.
- Top disease associations (Open Targets): speech disorder, Intellectual disability and hematocrit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 |
|---|---|
| UniProt accession | Q6UY18 |
| Gene | LINGO4 |
| Organism | Homo sapiens |
| Length | 593 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- speech disorder · score 0.37
- Intellectual disability · score 0.37
- hematocrit · score 0.26
- erythrocyte count · score 0.18
- hemoglobin measurement · score 0.16
- polymicrogyria · score 0.15
- serum gamma-glutamyl transferase measurement · score 0.08
- ulcerative colitis · score 0.07
- calcium measurement · score 0.06
- apolipoprotein A 1 measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6UY18-F1 | alphafold | PREDICTED | 85.51 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6UY18.
Amino-acid sequence (593 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LINGO4?
The strongest Open Targets associations for LINGO4 are speech disorder, Intellectual disability, hematocrit, erythrocyte count and hemoglobin measurement.
How long is the LINGO4 protein?
The Homo sapiens LINGO4 protein (UniProt Q6UY18) is 593 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6UY18 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6UY18 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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