Protocadherin Fat 4 (FAT4)
Homo sapiens — UniProt Q6V0I7
Gene: FAT4Homo sapiensSwissProt reviewed
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin Fat 4 (FAT4) is a protein from Homo sapiens identified by UniProt accession Q6V0I7, 4981 residues long. MolForge cross-references it against 0 known binders and 361 disease associations.
- UniProt accession: Q6V0I7; gene symbol FAT4.
- Organism: Homo sapiens.
- Length: 4981 amino acids.
- Top disease associations (Open Targets): Hennekam lymphangiectasia-lymphedema syndrome 2, van Maldergem syndrome 2 and Cerebro-facio-articular syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin Fat 4 |
|---|---|
| UniProt accession | Q6V0I7 |
| Gene | FAT4 |
| Organism | Homo sapiens |
| Length | 4981 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (361)
Diseases linked to this target (Open Targets).
- Hennekam lymphangiectasia-lymphedema syndrome 2 · score 0.76
- van Maldergem syndrome 2 · score 0.71
- Cerebro-facio-articular syndrome · score 0.60
- Periventricular heterotopia · score 0.50
- van Maldergem syndrome · score 0.49
- colorectal adenocarcinoma · score 0.43
- gastric adenocarcinoma · score 0.42
- Hennekam syndrome · score 0.41
- lymphoid neoplasm · score 0.41
- melanoma · score 0.40
3D Structure (10)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6V0I7-F6 | alphafold | PREDICTED | 85.55 | — |
| AF-Q6V0I7-F10 | alphafold | PREDICTED | 85.49 | — |
| AF-Q6V0I7-F2 | alphafold | PREDICTED | 85.47 | — |
| AF-Q6V0I7-F12 | alphafold | PREDICTED | 84.59 | — |
| AF-Q6V0I7-F15 | alphafold | PREDICTED | 84.41 | — |
| AF-Q6V0I7-F11 | alphafold | PREDICTED | 84.36 | — |
| AF-Q6V0I7-F5 | alphafold | PREDICTED | 84.34 | — |
| AF-Q6V0I7-F16 | alphafold | PREDICTED | 84.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6V0I7.
Amino-acid sequence (4981 residues)
MDLAPDRATG RPWLPLHTLS VSQLLRVFWL LSLLPGQAWV HGAEPRQVFQ VLEEQPPGTL VGTIQTRPGF TYRLSESHAL FAINSSTGAL YTTSTIDRES LPSDVINLVV LSSAPTYPTE VRVLVRDLND NAPVFPDPSI VVTFKEDSSS GRQVILDTAT DSDIGSNGVD HRSYRIIRGN EAGRFRLDIT LNPSGEGAFL HLVSKGGLDR EVTPQYQLLV EVEDKGEPKR RGYLQVNVTV QDINDNPPVF GSSHYQAGVP EDAVVGSSVL QVAAADADEG TNADIRYRLQ DEGTPFQMDP ETGLITVREP LDFEARRQYS LTVQAMDRGV PSLTGRAEAL IQLLDVNDND PVVKFRYFPA TSRYASVDEN AQVGTVVALL TVTDADSPAA NGNISVQILG GNEQRHFEVQ SSKVPNLSLI KVASALDRER IPSYNLTVSV SDNYGAPPGA AVQARSSVAS LVIFVNDIND HPPVFSQQVY RVNLSEEAPP GSYVSGISAT DGDSGLNANL RYSIVSGNGL GWFHISEHSG LVTTGSSGGL DRELASQIVL NISARDQGVH PKVSYAQLVV TLLDVNDEKP VFSQPEGYDV SVVENAPTGT ELLMLRATDG DLGDNGTVRF SLQEAETDRR SFRLDPVSGR LSTISSLDRE EQAFYSLLVL ATDLGSPPQS SMARINVSLL DINDNSPVFY PVQYFAHIKE NEPGGSYITT VSATDPDLGT NGTVKYSISA GDRSRFQVNA QSGVISTRMA LDREEKTAYQ LQIVATDGGN LQSPNQAIVT ITVLDTQDNP PVFSQVAYSF VVFENVALGY HVGSVSASTM DLNSNISYLI TTGDQKGMFA INQVTGQLTT ANVIDREEQS FYQLKVVASG GTVTGDTMVN ITVKDLNDNS PHFLQAIESV NVVENWQAGH SIFQAKAVDP DEGVNGMVLY SLKQNPKNLF AINEKNGTIS LLGPLDVHAG SYQIEILASD MGVPQLSSSV ILTVYVHDVN DNSPVFDQLS YEVTLSESEP VNSRFFKVQA SDKDSGANGE IAYTIAEGNT GDAFGIFPDG QLYIKSELDR ELQDRYVLMV VASDRAVEPL SATVNVTVIL EDVNDNRPLF NSTNYTFYFE EEQRAGSFVG KVSAVDKDFG PNGEVRYSFE MVQPDFELHA ISGEITNTHQ FDRESLMRRR GTAVFSFTVI ATDQGIPQPL KDQATVHVYM KDINDNAPKF LKDFYQATIS ESAANLTQVL RVSASDVDEG NNGLIHYSII KGNEERQFAI DSTSGQVTLI GKLDYEATPA YSLVIQAVDS GTIPLNSTCT LNIDILDEND NTPSFPKSTL FVDVLENMRI GELVSSVTAT DSDSGDNADL YYSITGTNNH GTFSISPNTG SIFLAKKLDF ETQSLYKLNI TAKDQGRPPR SSTMSVVIHV RDFNDNPPSF PPGDIFKSIV ENIPIGTSVI SVTAHDPDAD INGQLSYTII QQMPRGNHFT IDEVKGTIYT NAEIDREFAN LFELTVKAND QAVPIETRRY ALKNVTILVT DLNDNVPMFI SQNALAADPS AVIGSVLTTI MAADPDEGAN GEIEYEIING DTDTFIVDRY SGDLRVASAL VPSQLIYNLI VSATDLGPER RKSTTELTII LQGLDGPVFT QPKYITILKE GEPIGTNVIS IEAASPRGSE APVEYYIVSV RCEEKTVGRL FTIGRHTGII QTAAILDREQ GACLYLVDVY AIEKSTAFPR TQRAEVEITL QDINDNPPVF PTDMLDLTVE ENIGDGSKIM QLTAMDADEG ANALVTYTII SGADDSFRID PESGDLIATR RLDRERRSKY SLLVRADDGL QSSDMRINIT VSDVNDHTPK FSRPVYSFDI PEDTIPGSLV AAILATDDDS GVNGEITYIV NEDDEDGIFF LNPITGVFNL TRLLDYEVQQ YYILTVRAED GGGQFTTIRV YFNILDVNDN PPIFSLNSYS TSLMENLPVG STVLVFNVTD ADDGINSQLT YSIASGDSLG QFTVDKNGVL KVLKALDRES QSFYNLVVQV HDLPQIPASR FTSTAQVSII LLDVNDNPPT FLSPKLTYIP ENTPIDTVVF KAQATDPDSG PNSYIEYTLL NPLGNKFSIG TIDGEVRLTG ELDREEVSNY TLTVVATDKG QPSLSSSTEV VVMVLDINDN NPIFAQALYK VEINENTLTG TDIIQVFAAD GDEGTNGQVR YGIVNGNTNQ EFRIDSVTGA ITVAKPLDRE KTPTYHLTVQ ATDRGSTPRT DTSTVSIVLL DINDFVPVFE LSPYSVNVPE NLGTLPRTIL QVVARDDDRG SNSKLSYVLF GGNEDNAFTL SASGELGVTQ SLDRETKERF VLMITATDSG SPALTGTGTI NVIVDDVNDN VPTFASKAYF TTIPEDAPTG TDVLLVNASD ADASKNAVIR IIGGNSQFTI NPSTGQIITS ALLDRETKDN YTLVVVCSDA GSPEPLSSST SVLVTVTDVN DNPPRFQHHP YVTHIPSPTL PGSFVFAVTV TDADIGPNSE LHYSLSGRNS EKFHIDPLRG AIMAAGPLNG ASEVTFSVHV KDGGSFPKTD STTVTVRFVN KADFPKVRAK EQTFMFPENQ PVSSLVTTIT GSSLRGEPMS YYIASGNLGN TFQIDQLTGQ VSISQPLDFE KIQKYVVWIE ARDGGFPPFS SYEKLDITVL DVNDNAPIFK EDPFISEILE NLSPRKILTV SAMDKDSGPN GQLDYEIVNG NMENSFSINH ATGEIRSVRP LDREKVSHYV LTIKSSDKGS PSQSTSVKVM INILDENDNA PRFSQIFSAH VPENSPLGYT VTRVTTSDED IGINAISRYS IMDASLPFTI NPSTGDIVIS RPLNREDTDR YRIRVSAHDS GWTVSTDVTI FVTDINDNAP RFSRTSYYLD CPELTEIGSK VTQVFATDPD EGSNGQVFYF IKSQSEYFRI NATTGEIFNK QILKYQNVTG FSNVNINRHS FIVTSSDRGK PSLISETTVT INIVDSNDNA PQFLKSKYFT PVTKNVKVGT KLIRVTAIDD KDFGLNSEVE YFISNDNHLG KFKLDNDTGW ISVASSLISD LNQNFFITVT AKDKGNPPLS SQATVHITVT EENYHTPEFS QSHMSATIPE SHSIGSIVRT VSARDRDAAM NGLIKYSISS GNEEGIFAIN SSTGILTLAK ALDYELCQKH EMTISAIDGG WVARTGYCSV TVNVIDVNDN SPVFLSDDYF PTVLENAPSG TTVIHLNATD ADSGTNAVIA YTVQSSDSDL FVIDPNTGVI TTQGFLDFET KQSYHLTVKA FNVPDEERCS FATVNIQLKG TNEYVPRFVS KLYYFEISEA APKGTIVGEV FASDRDLGTD GEVHYLIFGN SRKKGFQINK KTGQIYVSGI LDREKEERVS LKVLAKNFGS IRGADIDEVT VNVTVLDAND PPIFTLNIYS VQISEGVPIG THVTFVSAFD SDSIPSWSRF SYFIGSGNEN GAFSINPQTG QITVTAELDR ETLPIYNLSV LAVDSGTPSA TGSASLLVTL EDINDNGPML TVSEGEVMEN KRPGTLVMTL QSTDPDLPPN QGPFTYYLLS TGPATSYFSL STAGVLSTTR EIDREQIADF YLSVVTKDSG VPQMSSTGTV HITVIDQNDN PSQSRTVEIF VNYYGNLFPG GILGSVKPQD PDVLDSFHCS LTSGVTSLFS IPGGTCDLNS QPRSTDGTFD LTVLSNDGVH STVTSNIRVF FAGFSNATVD NSILLRLGVP TVKDFLTNHY LHFLRIASSQ LTGLGTAVQL YSAYEENNRT FLLAAVKRNH NQYVNPSGVA TFFESIKEIL LRQSGVKVES VDHDSCVHGP CQNGGSCLRR LAVSSVLKSR ESLPVIIVAN EPLQPFLCKC LPGYAGSWCE IDIDECLPSP CHSGGTCHNL VGGFSCSCPD GFTGRACERD INECLQSPCK NGAICQNFPG SFNCVCKTGY TGKMCESSVN YCECNPCFNG GSCQSGVDSY YCHCPFGVFG KHCELNSYGF EELSYMEFPS LDPNNNYIYV KFATIKSHAL LLYNYDNQTG DRAEFLALEI AEERLRFSYN LGSGTYKLTT MKKVSDGHFH TVIARRAGMA ASLTVDSCSE NQEPGYCTVS NVAVSDDWTL DVQPNRVTVG GIRSLEPILQ RRGHVESHDF VGCIMEFAVN GRPLEPSQAL AAQGILDQCP RLEGACTRSP CQHGGTCMDY WSWQQCHCKE GLTGKYCEKS VTPDTALSLE GKGRLDYHMS QNEKREYLLR QSLRGAMLEP FGVNSLEVKF RTRSENGVLI HIQESSNYTT VKIKNGKVYF TSDAGIAGKV ERNIPEVYVA DGHWHTFLIG KNGTATVLSV DRIYNRDIIH PTQDFGGLDV LTISLGGIPP NQAHRDAQTA GFDGCIASMW YGGESLPFSG KHSLASISKT DPSVKIGCRG PNICASNPCW GDLLCINQWY AYRCVPPGDC ASHPCQNGGS CEPGLHSGFT CSCPDSHTGR TCEMVVACLG VLCPQGKVCK AGSPAGHVCV LSQGPEEISL PLWAVPAIVG SCATVLALLV LSLILCNQCR GKKAKNPKEE KKPKEKKKKG SENVAFDDPD NIPPYGDDMT VRKQPEGNPK PDIIERENPY LIYDETDIPH NSETIPSAPL ASPEQEIEHY DIDNASSIAP SDADIIQHYK QFRSHTPKFS IQRHSPLGFA RQSPMPLGAS SLTYQPSYGQ GLRTSSLSHS ACPTPNPLSR HSPAPFSKSS TFYRNSPARE LHLPIRDGNT LEMHGDTCQP GIFNYATRLG RRSKSPQAMA SHGSRPGSRL KQPIGQIPLE SSPPVGLSIE EVERLNTPRP RNPSICSADH GRSSSEEDCR RPLSRTRNPA DGIPAPESSS DSDSHESFTC SEMEYDREKP MVYTSRMPKL SQVNESDADD EDNYGARLKP RRYHGRRAEG GPVGTQAAAP GTADNTLPMK LGQQAGTFNW DNLLNWGPGF GHYVDVFKDL ASLPEKAAAN EEGKAGTTKP VPKDGEAEQY V
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAT4?
The strongest Open Targets associations for FAT4 are Hennekam lymphangiectasia-lymphedema syndrome 2, van Maldergem syndrome 2, Cerebro-facio-articular syndrome, Periventricular heterotopia and van Maldergem syndrome.
How long is the FAT4 protein?
The Homo sapiens FAT4 protein (UniProt Q6V0I7) is 4981 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6V0I7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6V0I7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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