Transcription factor AP-2-epsilon (TFAP2E)
Homo sapiens — UniProt Q6VUC0
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor AP-2-epsilon (TFAP2E) is a protein from Homo sapiens identified by UniProt accession Q6VUC0, 442 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.
- UniProt accession: Q6VUC0; gene symbol TFAP2E.
- Organism: Homo sapiens.
- Length: 442 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, head and neck squamous cell carcinoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor AP-2-epsilon |
|---|---|
| UniProt accession | Q6VUC0 |
| Gene | TFAP2E |
| Organism | Homo sapiens |
| Length | 442 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (35)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- head and neck squamous cell carcinoma · score 0.16
- endometrial cancer · score 0.15
- breast adenocarcinoma · score 0.10
- sex hormone-binding globulin measurement · score 0.08
- melanoma · score 0.08
- mean reticulocyte volume · score 0.07
- oral squamous cell carcinoma · score 0.06
- mean corpuscular volume · score 0.04
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6VUC0-F1 | alphafold | PREDICTED | 67.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6VUC0.
Amino-acid sequence (442 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TFAP2E?
The strongest Open Targets associations for TFAP2E are neurodegenerative disease, head and neck squamous cell carcinoma, endometrial cancer, breast adenocarcinoma and sex hormone-binding globulin measurement.
How long is the TFAP2E protein?
The Homo sapiens TFAP2E protein (UniProt Q6VUC0) is 442 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6VUC0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6VUC0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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