Phosphofurin acidic cluster sorting protein 1 (PACS1)
Homo sapiens — UniProt Q6VY07
Data last refreshed: (UniProt release unknown)
Key facts
Phosphofurin acidic cluster sorting protein 1 (PACS1) is a protein from Homo sapiens identified by UniProt accession Q6VY07, 963 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q6VY07; gene symbol PACS1.
- Organism: Homo sapiens.
- Length: 963 amino acids.
- Top disease associations (Open Targets): Schuurs-Hoeijmakers syndrome, Intellectual disability and HIV infection.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phosphofurin acidic cluster sorting protein 1 |
|---|---|
| UniProt accession | Q6VY07 |
| Gene | PACS1 |
| Organism | Homo sapiens |
| Length | 963 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- Schuurs-Hoeijmakers syndrome · score 0.71
- Intellectual disability · score 0.63
- HIV infection · score 0.50
- Intellectual disability - craniofacial dysmorphism - cryptorchidism · score 0.46
- genetic disorder · score 0.41
- Neurodevelopmental disorder · score 0.34
- Global developmental delay · score 0.34
- Horseshoe kidney · score 0.34
- Mitral valve prolapse · score 0.34
- Aortic root aneurysm · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6VY07-F1 | alphafold | PREDICTED | 64.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6VY07.
Amino-acid sequence (963 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PACS1?
The strongest Open Targets associations for PACS1 are Schuurs-Hoeijmakers syndrome, Intellectual disability, HIV infection, Intellectual disability - craniofacial dysmorphism - cryptorchidism and genetic disorder.
How long is the PACS1 protein?
The Homo sapiens PACS1 protein (UniProt Q6VY07) is 963 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6VY07 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6VY07 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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