Developmental pluripotency-associated protein 3 (DPPA3)
Homo sapiens — UniProt Q6W0C5
Data last refreshed: (UniProt release unknown)
Key facts
Developmental pluripotency-associated protein 3 (DPPA3) is a protein from Homo sapiens identified by UniProt accession Q6W0C5, 159 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q6W0C5; gene symbol DPPA3.
- Organism: Homo sapiens.
- Length: 159 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, retinal vein occlusion and Female infertility due to fertilization defect.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Developmental pluripotency-associated protein 3 |
|---|---|
| UniProt accession | Q6W0C5 |
| Gene | DPPA3 |
| Organism | Homo sapiens |
| Length | 159 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- retinal vein occlusion · score 0.14
- Female infertility due to fertilization defect · score 0.08
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.07
- female infertility due to oocyte meiotic arrest · score 0.07
- premature ovarian failure 19 · score 0.06
- female infertility due to zona pellucida defect · score 0.06
- oocyte maturation defect 11 · score 0.06
- Rare genetic female infertility · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6W0C5-F1 | alphafold | PREDICTED | 63.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6W0C5.
Amino-acid sequence (159 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPPA3?
The strongest Open Targets associations for DPPA3 are neurodegenerative disease, retinal vein occlusion, Female infertility due to fertilization defect, neoplasm and hepatocellular carcinoma.
How long is the DPPA3 protein?
The Homo sapiens DPPA3 protein (UniProt Q6W0C5) is 159 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6W0C5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6W0C5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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