BCL-6 corepressor (BCOR)
Homo sapiens — UniProt Q6W2J9
Data last refreshed: (UniProt release unknown)
Key facts
BCL-6 corepressor (BCOR) is a protein from Homo sapiens identified by UniProt accession Q6W2J9, 1755 residues long. MolForge cross-references it against 0 known binders and 438 disease associations.
- UniProt accession: Q6W2J9; gene symbol BCOR.
- Organism: Homo sapiens.
- Length: 1755 amino acids.
- Top disease associations (Open Targets): microphthalmia, syndromic 2, chronic lymphocytic leukemia and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BCL-6 corepressor |
|---|---|
| UniProt accession | Q6W2J9 |
| Gene | BCOR |
| Organism | Homo sapiens |
| Length | 1755 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (438)
Diseases linked to this target (Open Targets).
- microphthalmia, syndromic 2 · score 0.82
- chronic lymphocytic leukemia · score 0.53
- acute myeloid leukemia · score 0.49
- endometrial cancer · score 0.48
- genetic disorder · score 0.47
- gastric adenocarcinoma · score 0.44
- Developmental cataract · score 0.43
- early-onset non-syndromic cataract · score 0.43
- lymphoid neoplasm · score 0.41
- colorectal adenocarcinoma · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6W2J9-F1 | alphafold | PREDICTED | 39.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6W2J9.
Amino-acid sequence (1755 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BCOR?
The strongest Open Targets associations for BCOR are microphthalmia, syndromic 2, chronic lymphocytic leukemia, acute myeloid leukemia, endometrial cancer and genetic disorder.
How long is the BCOR protein?
The Homo sapiens BCOR protein (UniProt Q6W2J9) is 1755 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6W2J9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6W2J9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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