Cell cycle checkpoint control protein RAD9B (RAD9B)

About Cell cycle checkpoint control protein RAD9B

Cell cycle checkpoint control protein RAD9B (RAD9B) is a protein from Homo sapiens identified by UniProt accession Q6WBX8, 426 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.

Target properties

Protein name	Cell cycle checkpoint control protein RAD9B
UniProt accession	Q6WBX8
Gene	RAD9B
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (44)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
neural tube defect · score 0.48
endometrial cancer · score 0.27
calcium measurement · score 0.24
esophageal cancer · score 0.21
pancreatic adenocarcinoma · score 0.20
gastric adenocarcinoma · score 0.17
body mass index · score 0.15
peak expiratory flow · score 0.15
body fat percentage · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6WBX8-F1	alphafold	PREDICTED	69.58	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6WBX8.

Amino-acid sequence (426 residues)

MLKCVMSGSQ VKVFGKAVQA LSRISDEFWL DPSKKGLALR CVNSSRSAYG CVLFSPVFFQ HYQWSALVKM SENELDTTLH LKCKLGMKSI LPIFRCLNSL ERNIEKCRIF TRSDKCKVVI QFFYRHGIKR THNICFQESQ PLQVIFDKNV CTNTLMIQPR LLADAIVLFT SSQEEVTLAV TPLNFCLKSS NEESMDLSNA VHSEMFVGSD EFDFFQIGMD TEITFCFKEL KGILTFSEAT HAPISIYFDF PGKPLALSID DMLVEANFIL ATLADEQSRA SSPQSLCLSQ KRKRSDLIEK KAGKNVTGQA LECISKKAAP RRLYPKETLT NISALENCGS PAMKRVDGDV SEVSESSVSN TEEVPGSLCL RKFSCMFFGA VSSDQQEHFN HPFDSLARAS DSEEDMNNVC CRKEFNGSDA KYFCII

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards