Myosin phosphatase Rho-interacting protein (MPRIP)
Homo sapiens — UniProt Q6WCQ1
Data last refreshed: (UniProt release unknown)
Key facts
Myosin phosphatase Rho-interacting protein (MPRIP) is a protein from Homo sapiens identified by UniProt accession Q6WCQ1, 1025 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q6WCQ1; gene symbol MPRIP.
- Organism: Homo sapiens.
- Length: 1025 amino acids.
- Top disease associations (Open Targets): Birt-Hogg-Dube syndrome, hereditary neoplastic syndrome and Inherited cancer-predisposing syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Myosin phosphatase Rho-interacting protein |
|---|---|
| UniProt accession | Q6WCQ1 |
| Gene | MPRIP |
| Organism | Homo sapiens |
| Length | 1025 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- Birt-Hogg-Dube syndrome · score 0.57
- hereditary neoplastic syndrome · score 0.57
- Inherited cancer-predisposing syndrome · score 0.57
- cancer · score 0.54
- familial spontaneous pneumothorax · score 0.54
- mosaic trisomy 17 · score 0.52
- Potocki-Lupski syndrome · score 0.52
- nonpapillary renal cell carcinoma · score 0.52
- colorectal cancer · score 0.51
- Birt-Hogg-Dube syndrome 1 · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6WCQ1-F1 | alphafold | PREDICTED | 64.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6WCQ1.
Amino-acid sequence (1025 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MPRIP?
The strongest Open Targets associations for MPRIP are Birt-Hogg-Dube syndrome, hereditary neoplastic syndrome, Inherited cancer-predisposing syndrome, cancer and familial spontaneous pneumothorax.
How long is the MPRIP protein?
The Homo sapiens MPRIP protein (UniProt Q6WCQ1) is 1025 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6WCQ1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6WCQ1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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