Sclerostin domain-containing protein 1 (SOSTDC1)
Homo sapiens — UniProt Q6X4U4
Data last refreshed: (UniProt release unknown)
Key facts
Sclerostin domain-containing protein 1 (SOSTDC1) is a protein from Homo sapiens identified by UniProt accession Q6X4U4, 206 residues long. MolForge cross-references it against 0 known binders and 247 disease associations.
- UniProt accession: Q6X4U4; gene symbol SOSTDC1.
- Organism: Homo sapiens.
- Length: 206 amino acids.
- Top disease associations (Open Targets): Huntington disease, age at onset and PHF-tau measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sclerostin domain-containing protein 1 |
|---|---|
| UniProt accession | Q6X4U4 |
| Gene | SOSTDC1 |
| Organism | Homo sapiens |
| Length | 206 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (247)
Diseases linked to this target (Open Targets).
- Huntington disease · score 0.18
- age at onset · score 0.18
- PHF-tau measurement · score 0.13
- tooth agenesis · score 0.11
- non-small cell lung carcinoma · score 0.10
- Hypoplastic amelogenesis imperfecta · score 0.10
- dentin dysplasia type I · score 0.10
- tooth agenesis, selective, 7 · score 0.10
- Hypomaturation amelogenesis imperfecta · score 0.10
- taurodontism · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6X4U4-F1 | alphafold | PREDICTED | 68.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6X4U4.
Amino-acid sequence (206 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SOSTDC1?
The strongest Open Targets associations for SOSTDC1 are Huntington disease, age at onset, PHF-tau measurement, tooth agenesis and non-small cell lung carcinoma.
How long is the SOSTDC1 protein?
The Homo sapiens SOSTDC1 protein (UniProt Q6X4U4) is 206 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6X4U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6X4U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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