NMDA receptor synaptonuclear signaling and neuronal migration factor (NSMF)
Homo sapiens — UniProt Q6X4W1
Data last refreshed: (UniProt release unknown)
Key facts
NMDA receptor synaptonuclear signaling and neuronal migration factor (NSMF) is a protein from Homo sapiens identified by UniProt accession Q6X4W1, 530 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: Q6X4W1; gene symbol NSMF.
- Organism: Homo sapiens.
- Length: 530 amino acids.
- Top disease associations (Open Targets): hypogonadotropic hypogonadism, pituitary stalk interruption syndrome and Kallmann syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NMDA receptor synaptonuclear signaling and neuronal migration factor |
|---|---|
| UniProt accession | Q6X4W1 |
| Gene | NSMF |
| Organism | Homo sapiens |
| Length | 530 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- hypogonadotropic hypogonadism · score 0.38
- pituitary stalk interruption syndrome · score 0.34
- Kallmann syndrome · score 0.27
- male infertility with azoospermia or oligozoospermia due to single gene mutation · score 0.27
- creatinine measurement · score 0.09
- calcium measurement · score 0.08
- Female infertility due to fertilization defect · score 0.07
- 46,XX gonadal dysgenesis · score 0.07
- primary ovarian insufficiency · score 0.07
- Testicular regression syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6X4W1-F1 | alphafold | PREDICTED | 64.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6X4W1.
Amino-acid sequence (530 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSMF?
The strongest Open Targets associations for NSMF are hypogonadotropic hypogonadism, pituitary stalk interruption syndrome, Kallmann syndrome, male infertility with azoospermia or oligozoospermia due to single gene mutation and creatinine measurement.
How long is the NSMF protein?
The Homo sapiens NSMF protein (UniProt Q6X4W1) is 530 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6X4W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6X4W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.