F-box/WD repeat-containing protein 12 (FBXW12)
Homo sapiens — UniProt Q6X9E4
Data last refreshed: (UniProt release unknown)
Key facts
F-box/WD repeat-containing protein 12 (FBXW12) is a protein from Homo sapiens identified by UniProt accession Q6X9E4, 464 residues long. MolForge cross-references it against 0 known binders and 156 disease associations.
- UniProt accession: Q6X9E4; gene symbol FBXW12.
- Organism: Homo sapiens.
- Length: 464 amino acids.
- Top disease associations (Open Targets): mathematical ability, cystatin C measurement and cognitive function measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | F-box/WD repeat-containing protein 12 |
|---|---|
| UniProt accession | Q6X9E4 |
| Gene | FBXW12 |
| Organism | Homo sapiens |
| Length | 464 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (156)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.28
- cystatin C measurement · score 0.21
- cognitive function measurement · score 0.18
- glomerular filtration rate · score 0.17
- Blackfan-Diamond anemia · score 0.09
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- hemoglobin C-beta-thalassemia syndrome · score 0.06
- alpha-thalassemia-myelodysplastic syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6X9E4-F1 | alphafold | PREDICTED | 88.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6X9E4.
Amino-acid sequence (464 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FBXW12?
The strongest Open Targets associations for FBXW12 are mathematical ability, cystatin C measurement, cognitive function measurement, glomerular filtration rate and Blackfan-Diamond anemia.
How long is the FBXW12 protein?
The Homo sapiens FBXW12 protein (UniProt Q6X9E4) is 464 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6X9E4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6X9E4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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