Lipase member I (LIPI)

About Lipase member I

Lipase member I (LIPI) is a protein from Homo sapiens identified by UniProt accession Q6XZB0, 460 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Lipase member I
UniProt accession	Q6XZB0
Gene	LIPI
Organism	Homo sapiens
Length	460 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

neurofibrillary tangles measurement · score 0.32
glucuronate measurement · score 0.22
drug use measurement · score 0.18
lung adenocarcinoma · score 0.11
cutaneous melanoma · score 0.11
Hyperlipoproteinemia type 4 · score 0.11
esophageal cancer · score 0.10
squamous cell lung carcinoma · score 0.10
glioblastoma multiforme · score 0.10
YKL40 measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6XZB0-F1	alphafold	PREDICTED	89.41	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6XZB0.

Amino-acid sequence (460 residues)

MRVYIFLCLM CWVRSDNKRP CLEFSQLSVK DSFRDLFIPR IETILMMYTR NNLNCAEPLF EQNNSLNVNF NTQKKTVWLI HGYRPVGSIP LWLQNFVRIL LNEEDMNVIV VDWSRGATTF IYNRAVKNTR KVAVSLSVHI KNLLKHGASL DNFHFIGVSL GAHISGFVGK IFHGQLGRIT GLDPAGPRFS RKPPYSRLDY TDAKFVDVIH SDSNGLGIQE PLGHIDFYPN GGNKQPGCPK SIFSGIQFIK CNHQRAVHLF MASLETNCNF ISFPCRSYKD YKTSLCVDCD CFKEKSCPRL GYQAKLFKGV LKERMEGRPL RTTVFLDTSG TYPFCTYYFV LSIIVPDKTM MDGSFSFKLL NQLGMIEEPR LYEKNKPFYK LQEVKILAQF YNDFVNISSI GLTYFQSSNL QCSTCTYKIQ SLMLKSLTYP ERPPLCRYNI VLKDREEVFL NPNTCTPKNT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards