Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2)
Homo sapiens — UniProt Q6Y1H2
Data last refreshed: (UniProt release unknown)
Key facts
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (HACD2) is a protein from Homo sapiens identified by UniProt accession Q6Y1H2, 254 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q6Y1H2; gene symbol HACD2.
- Organism: Homo sapiens.
- Length: 254 amino acids.
- Top disease associations (Open Targets): body mass index, electrocardiography and sleep duration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 |
|---|---|
| UniProt accession | Q6Y1H2 |
| Gene | HACD2 |
| Organism | Homo sapiens |
| Length | 254 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- body mass index · score 0.42
- electrocardiography · score 0.37
- sleep duration · score 0.29
- coffee consumption measurement · score 0.27
- tea consumption measurement · score 0.27
- erythrocyte count · score 0.10
- body fat percentage · score 0.05
- type 2 diabetes mellitus · score 0.04
- short stature due to GHSR deficiency · score 0.03
- high density lipoprotein cholesterol measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6Y1H2-F1 | alphafold | PREDICTED | 77.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6Y1H2.
Amino-acid sequence (254 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HACD2?
The strongest Open Targets associations for HACD2 are body mass index, electrocardiography, sleep duration, coffee consumption measurement and tea consumption measurement.
How long is the HACD2 protein?
The Homo sapiens HACD2 protein (UniProt Q6Y1H2) is 254 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6Y1H2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6Y1H2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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