DnaJ homolog subfamily C member 14 (DNAJC14)
Homo sapiens — UniProt Q6Y2X3
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily C member 14 (DNAJC14) is a protein from Homo sapiens identified by UniProt accession Q6Y2X3, 702 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q6Y2X3; gene symbol DNAJC14.
- Organism: Homo sapiens.
- Length: 702 amino acids.
- Top disease associations (Open Targets): isolated hyperchlorhidrosis, congenital lethal erythroderma and hearing loss-familial salivary gland insensitivity to aldosterone syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily C member 14 |
|---|---|
| UniProt accession | Q6Y2X3 |
| Gene | DNAJC14 |
| Organism | Homo sapiens |
| Length | 702 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- isolated hyperchlorhidrosis · score 0.03
- congenital lethal erythroderma · score 0.03
- hearing loss-familial salivary gland insensitivity to aldosterone syndrome · score 0.03
- heart rate · score 0.02
- response to beta blocker · score 0.02
- Rheumatoid arthritis · score 0.01
- infect · score 0.01
- infection · score 0.01
- Flavivirus Infections · score 0.00
- viral disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6Y2X3-F1 | alphafold | PREDICTED | 59.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6Y2X3.
Amino-acid sequence (702 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJC14?
The strongest Open Targets associations for DNAJC14 are isolated hyperchlorhidrosis, congenital lethal erythroderma, hearing loss-familial salivary gland insensitivity to aldosterone syndrome, heart rate and response to beta blocker.
How long is the DNAJC14 protein?
The Homo sapiens DNAJC14 protein (UniProt Q6Y2X3) is 702 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6Y2X3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6Y2X3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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