GRB10-interacting GYF protein 2 (GIGYF2)
Homo sapiens — UniProt Q6Y7W6
Data last refreshed: (UniProt release unknown)
Key facts
GRB10-interacting GYF protein 2 (GIGYF2) is a protein from Homo sapiens identified by UniProt accession Q6Y7W6, 1299 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.
- UniProt accession: Q6Y7W6; gene symbol GIGYF2.
- Organism: Homo sapiens.
- Length: 1299 amino acids.
- Top disease associations (Open Targets): Hereditary late-onset Parkinson disease, Young adult-onset Parkinsonism and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GRB10-interacting GYF protein 2 |
|---|---|
| UniProt accession | Q6Y7W6 |
| Gene | GIGYF2 |
| Organism | Homo sapiens |
| Length | 1299 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (144)
Diseases linked to this target (Open Targets).
- Hereditary late-onset Parkinson disease · score 0.69
- Young adult-onset Parkinsonism · score 0.67
- neurodegenerative disease · score 0.53
- Leber congenital amaurosis 16 · score 0.52
- Leber congenital amaurosis · score 0.38
- Parkinson disease · score 0.33
- snowflake vitreoretinal degeneration · score 0.31
- schizophrenia · score 0.28
- creatinine measurement · score 0.25
- lean body mass · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q6Y7W6-F1 | alphafold | PREDICTED | 56.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6Y7W6.
Amino-acid sequence (1299 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GIGYF2?
The strongest Open Targets associations for GIGYF2 are Hereditary late-onset Parkinson disease, Young adult-onset Parkinsonism, neurodegenerative disease, Leber congenital amaurosis 16 and Leber congenital amaurosis.
How long is the GIGYF2 protein?
The Homo sapiens GIGYF2 protein (UniProt Q6Y7W6) is 1299 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q6Y7W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q6Y7W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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