tRNA (32-2'-O)-methyltransferase regulator THADA (THADA)

Homo sapiens — UniProt Q6YHU6

Gene: THADAHomo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

tRNA (32-2'-O)-methyltransferase regulator THADA (THADA) is a protein from Homo sapiens identified by UniProt accession Q6YHU6, 1953 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.

UniProt accession: Q6YHU6; gene symbol THADA.
Organism: Homo sapiens.
Length: 1953 amino acids.
Top disease associations (Open Targets): type 2 diabetes mellitus, heel bone mineral density and neutrophil count.
3D structure: AlphaFold model available.

Target properties

Protein name	tRNA (32-2'-O)-methyltransferase regulator THADA
UniProt accession	Q6YHU6
Gene	THADA
Organism	Homo sapiens
Length	1953 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (157)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.41
heel bone mineral density · score 0.38
neutrophil count · score 0.37
prostate carcinoma · score 0.36
systolic blood pressure · score 0.36
Crohn's disease · score 0.35
triglyceride measurement · score 0.35
BMI-adjusted waist-hip ratio · score 0.35
polycystic ovary syndrome · score 0.34
diabetes mellitus · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6YHU6-F1	alphafold	PREDICTED	79.89	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6YHU6.

Amino-acid sequence (1953 residues)

MGVKKKKEMQ VAALTICHQD LETLKSFADV EGKNLASLLL HCVQLTDGVS QIHYIKQIVP LLEKADKNGM CDPTIQSCLD ILAGIYLSLS LKNPLKKVLA SSLNSLPDFF LPEAMHRFTS RLQEELNTTD LYSYRKVTDN ISSCMENFNL GRASVNNLLK NVLHFLQKSL IEILEENRKC AGNHIIQTQL MNDLLVGIRV SMMLVQKVQD FQGNLWKTSD SPIWQNMCGL LSIFTKVLSD DDLLQTVQST SGLAIILFIK TMFHPSEKIP HLISSVLLRS VDCTSVPEWF MSSCRSLCCG DISQSAVLFL CQGTLAMLDW QNGSMGRSGE ALLLDTAHVL FTLSSQIKEP TLEMFLSRIL ASWTNSAIQV LESSSPSLTD SLNGNSSIVG RLLEYVYTHW EHPLDALRHQ TKIMFKNLLQ MHRLTVEGAD FVPDPFFVEL TESLLRLEWH IKGKYTCLGC LVECIGVEHI LAIDKTIPSQ ILEVMGDQSL VPYASDLLET MFRNHKSHLK SQTAESSWID QWHETWVSPL LFILCEGNLD QKSYVIDYYL PKLLSYSPES LQYMVKILQT SIDAKTGQEQ SFPSLGSCNS RGALGALMAC LRIARAHGHL QSATDTWENL VSDARIKQGL IHQHCQVRID TLGLLCESNR STEIVSMEEM QWIQFFITYN LNSQSPGVRQ QICSLLKKLF CRIQESSQVL YKLEQSKSKR EPENELTKQH PSVSLQQYKN FMSSICNSLF EALFPGSSYS TRFSALTILG SIAEVFHVPE GRIYTVYQLS HDIDVGRFQT LMECFTSTFE DVKILAFDLL MKLSKTAVHF QDSGKLQGLF QAALELSTST KPYDCVTASY LLNFLIWQDA LPSSLSAYLT QQVACDNGDR PAAVVERNTL MVIKCLMENL EEEVSQAENS LLQAAAAFPM YGRVHCITGA LQKLSLNSLQ LVSEWRPVVE KLLLMSYRLS TVVSPVIQSS SPEGLIPMDT DSESASRLQM ILNEIQPRDT NDYFNQAKIL KEHDSFDMKD LNASVVNIDT STEIKGKEVK TCDVTAQMVL VCCWRSMKEV ALLLGMLCQL LPMQPVPESS DGLLTVEQVK EIGDYFKQHL LQSRHRGAFE LAYTGFVKLT EVLNRCPNVS LQKLPEQWLW SVLEEIKCSD PSSKLCATRR SAGIPFYIQA LLASEPKKGR MDLLKITMKE LISLAGPTDD IQSTVPQVHA LNILRALFRD TRLGENIIPY VADGAKAAIL GFTSPVWAVR NSSTLLFSAL ITRIFGVKRA KDEHSKTNRM TGREFFSRFP ELYPFLLKQL ETVANTVDSD MGEPNRHPSM FLLLLVLERL YASPMDGTSS ALSMGPFVPF IMRCGHSPVY HSREMAARAL VPFVMIDHIP NTIRTLLSTL PSCTDQCFRQ NHIHGTLLQV FHLLQAYSDS KHGTNSDFQH ELTDITVCTK AKLWLAKRQN PCLVTRAVYI DILFLLTCCL NRSAKDNQPV LESLGFWEEV RGIISGSELI TGFPWAFKVP GLPQYLQSLT RLAIAAVWAA AAKSGERETN VPISFSQLLE SAFPEVRSLT LEALLEKFLA AASGLGEKGV PPLLCNMGEK FLLLAMKENH PECFCKILKI LHCMDPGEWL PQTEHCVHLT PKEFLIWTMD IASNERSEIQ SVALRLASKV ISHHMQTCVE NRELIAAELK QWVQLVILSC EDHLPTESRL AVVEVLTSTT PLFLTNPHPI LELQDTLALW KCVLTLLQSE EQAVRDAATE TVTTAMSQEN TCQSTEFAFC QVDASIALAL ALAVLCDLLQ QWDQLAPGLP ILLGWLLGES DDLVACVESM HQVEEDYLFE KAEVNFWAET LIFVKYLCKH LFCLLSKSGW RPPSPEMLCH LQRMVSEQCH LLSQFFRELP PAAEFVKTVE FTRLRIQEER TLACLRLLAF LEGKEGEDTL VLSVWDSYAE SRQLTLPRTE AAC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with THADA?

The strongest Open Targets associations for THADA are type 2 diabetes mellitus, heel bone mineral density, neutrophil count, prostate carcinoma and systolic blood pressure.

How long is the THADA protein?

The Homo sapiens THADA protein (UniProt Q6YHU6) is 1953 amino acids long.

Browse: Targets: T · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q6YHU6 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q6YHU6 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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