Transmembrane protein 64 (TMEM64)

About Transmembrane protein 64

Transmembrane protein 64 (TMEM64) is a protein from Homo sapiens identified by UniProt accession Q6YI46, 380 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.

Target properties

Protein name	Transmembrane protein 64
UniProt accession	Q6YI46
Gene	TMEM64
Organism	Homo sapiens
Length	380 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (99)

Diseases linked to this target (Open Targets).

serum metabolite measurement · score 0.29
insomnia measurement · score 0.25
alkaline phosphatase measurement · score 0.21
chronotype measurement · score 0.20
hematocrit · score 0.15
adolescent idiopathic scoliosis · score 0.15
red blood cell density measurement · score 0.14
mean corpuscular volume · score 0.12
hemoglobin measurement · score 0.11
metabolite measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q6YI46-F1	alphafold	PREDICTED	65.29	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q6YI46.

Amino-acid sequence (380 residues)

MRSPGGILLQ ALPRLLQHAA LPGLAELPAR WALPRGAGGD GPADRLPRGG GASAAAAAAA ASGALLGAYL ERHGPPEASE LPEPGGALAG GPGSGGGGVV VGVAEVRNWR CCCLGSTCWC RSLVLVCVLA ALCFASLALV RRYLHHLLLW VESLDSLLGV LLFVVGFIVV SFPCGWGYIV LNVAAGYLYG FVLGMGLMMV GVLIGTFIAH VVCKRLLTAW VAARIQSSEK LSAVIRVVEG GSGLKVVALA RLTPIPFGLQ NAVFSITDLS LPNYLMASSV GLLPTQLLNS YLGTTLRTME DVIAEQSVSG YFVFCLQIII SIGLMFYVVH RAQVELNAAI VACEMELKSS LVKGNQPNTS GSSFYNKRTL TFSGGGINVV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards